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The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the
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77 , Journal: Pharmacology Research & Perspectives
Article Title: Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects
doi: 10.1002/prp2.1243
Figure Lengend Snippet: Hormonal regulation of the hypothalamic melanocortin system. The function of MC4R is influenced by orexigenic AgRP/NPY neurons, which inhibit it, and anorexigenic POMC neurons, which stimulate it. Gut peptides, such as ghrelin, PYY, and GLP‐1, as well as other factors, for example, leptin, modulate AgRP/NPY and POMC activity impacting food intake. AgRP/NPY are stimulated by ghrelin and inhibited by PYY, GLP‐1 (indirectly), and leptin. POMC are stimulated by GLP‐1 and leptin, while ghrelin indirectly inhibits it.
Article Snippet: Notably, the
Techniques: Activity Assay